Retargeting of herpes simplex virus (HSV) vectors
نویسندگان
چکیده
منابع مشابه
Retargeting of herpes simplex virus (HSV) vectors.
Gene therapy applications depend on vector delivery and gene expression in the appropriate target cell. Vector infection relies on the distribution of natural virus receptors that may either not be present on the desired target cell or distributed in a manner to give off-target gene expression. Some viruses display a very limited host range, while others, including herpes simplex virus (HSV), c...
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Gene delivery to the nervous system represents perhaps the ultimate challenge of gene therapy in view of the complexity of this system, the wide variety of intractable neurological diseases and the need to deliver the gene to non-dividing cells. Although a variety of systems for such gene delivery are under development, herpes simplex virus has unique advantages in terms of its large genome siz...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2016
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2016.08.007